Codeine has actually been uncovered as an endogenous compound, in conjunction with morphine, inside the brains of nonhuman primates with depolarized neurons, indicating that codeine may perhaps functionality as a neurotransmitter or neuromodulator inside the central anxious system.
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^ S4 provided that in drug combos; see #Authorized position. ^ Class C1 only for small doses; see exemptions on Portaria SVS/MS 344/98. ^ Pharmacy drugs if procured in the reduced dose from a accredited pharmacy or in small dose drug blend; see #Lawful status.
Evidence supporting the hypothesis that ultrarapid metabolizers may possibly get higher analgesia from codeine on account of greater morphine development is limited to circumstance stories.[forty two]
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